By Alfred N. Fonteh,Robert L. Wykle

ISBN-10: 3764369485

ISBN-13: 9783764369484

Arachidonic acid (AA) and different 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of irritation often called eicosanoids. those mediators are severe in affliction procedures and in regulating basic cellphone functionality. home improvement is critical in retaining homeostasis and in regulating phone functionality by way of dictating how PUFAs are switched over to lipid mediators of irritation. therefore, PUFA home improvement is a serious method within the biosynthesis of a large number of mediators, and figuring out this method will get to the bottom of larger healing pursuits for controlling inflammatory ailments similar to bronchial asthma and Alzheimer’s disease.
AA metabolism is defined in an built-in context linking the reworking methods with the biosynthesis of mediators and ailments. via following the move of the substrate (AA), the quantity describes how upstream biosynthetic pathways impression the formation of lipid mediators of irritation, displaying the metabolic interrelationship among all AA-derived mediators.

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Arachidonate Remodeling and Inflammation (Progress in Inflammation Research) by Alfred N. Fonteh,Robert L. Wykle


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